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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-DMN / Desmuslin / Synemin Antibody (aa329-580, clone 2F4)
Anti-DMN / Desmuslin / Synemin Antibody (aa329-580, clone 2F4)
Mouse Anti Human Monoclonal Antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | O15061 |
| Predicted | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | 2F4 |
| Calculated MW | 172868 Da |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 23336 |
|---|---|
| Alias Symbol | SYNM |
| Other Names | SYNM, Desmuslin, KIAA0353, SYN, Synemin beta, Synemin, DMN, Synemin alpha |
| Target/Specificity | Human DMN / Desmuslin / Synemin |
| Reconstitution & Storage | PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide Store at -20°C. Minimize freezing and thawing. |
| Precautions | Anti-DMN / Desmuslin / Synemin Antibody (aa329-580, clone 2F4) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SYNM (HGNC:24466) |
|---|---|
| Synonyms | DMN, KIAA0353, SYN |
| Function | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. |
| Cellular Location | Cytoplasm, cytoskeleton. Cell junction, adherens junction. Note=There are at least two distinct SYNM subpopulations, one in which SYMN interacts with DES within the Z-lines, and another in which it interacts with both DTNA and DES at the costamere |
| Tissue Location | Isoform 2 is strongly detected in adult heart, fetal skeletal muscles and fetal heart. Isoform 1 is weakly detected in fetal heart and also in fetal skeletal muscle. Isoform 1 and isoform 2 are detected in adult bladder (at protein level). The mRNA is predominantly expressed in heart and muscle with some expression in brain which may be due to tissue-specific isoforms |
Research Areas
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