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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   GPCR Antibodies   >   Anti-DMN / Desmuslin / Synemin Antibody (aa329-580, clone 2F4)    

Anti-DMN / Desmuslin / Synemin Antibody (aa329-580, clone 2F4)

Mouse Anti Human Monoclonal Antibody

  • IHC-P - Anti-DMN / Desmuslin / Synemin Antibody (aa329-580, clone 2F4)  ALS17324
    Human Colon, Submucosa: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IHC-P - Anti-DMN / Desmuslin / Synemin Antibody (aa329-580, clone 2F4)  ALS17324
    Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O15061
Predicted Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 2F4
Calculated MW 172768 Da
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 23336
Alias Symbol SYNM
Other Names SYNM, Desmuslin, KIAA0353, SYN, Synemin beta, Synemin, DMN, Synemin alpha
Target/Specificity Human DMN / Desmuslin / Synemin
Reconstitution & Storage PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide Store at -20°C. Minimize freezing and thawing.
PrecautionsAnti-DMN / Desmuslin / Synemin Antibody (aa329-580, clone 2F4) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms DMN, KIAA0353, SYN
Function Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells.
Cellular Location Cytoplasm, cytoskeleton. Cell junction, adherens junction. Note=There are at least two distinct SYNM subpopulations, one in which SYMN interacts with DES within the Z- lines, and another in which it interacts with both DTNA and DES at the costamere
Tissue Location Isoform 2 is strongly detected in adult heart, fetal skeletal muscles and fetal heart. Isoform 1 is weakly detected in fetal heart and also in fetal skeletal muscle. Isoform 1 and isoform 2 are detected in adult bladder (at protein level) The mRNA is predominantly expressed in heart and muscle with some expression in brain which may be due to tissue-specific isoforms
Research Areas
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$ 395.00
Cat# ALS17324
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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