|Calculated MW||172768 Da|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||SYNM, Desmuslin, KIAA0353, SYN, Synemin beta, Synemin, DMN, Synemin alpha|
|Target/Specificity||Human DMN / Desmuslin / Synemin|
|Reconstitution & Storage||PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide Store at -20°C. Minimize freezing and thawing.|
|Precautions||Anti-DMN / Desmuslin / Synemin Antibody (aa329-580, clone 2F4) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DMN, KIAA0353, SYN|
|Function||Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell junction, adherens junction. Note=There are at least two distinct SYNM subpopulations, one in which SYMN interacts with DES within the Z- lines, and another in which it interacts with both DTNA and DES at the costamere|
|Tissue Location||Isoform 2 is strongly detected in adult heart, fetal skeletal muscles and fetal heart. Isoform 1 is weakly detected in fetal heart and also in fetal skeletal muscle. Isoform 1 and isoform 2 are detected in adult bladder (at protein level) The mRNA is predominantly expressed in heart and muscle with some expression in brain which may be due to tissue-specific isoforms|
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