|Application ||WB, IHC-P, E, IP, ID, Flo|
|Calculated MW||45205 Da|
|Dilution||ELISA, Flo, ID, IHC-P (5 µg/ml), IP, WB|
|Other Names||HP, Binding peptide, Haptoglobin alpha(1S)-beta, Haptoglobin, beta polypeptide, Haptoglobin, Haptoglobin alpha(2FS)-beta, Haptoglobin, alpha polypeptide, HP2ALPHA2, BP, Zonulin, HPA1S|
|Reconstitution & Storage||10 mM sodium phosphate, 0.15 M sodium chloride, pH 7.2, 0.05% sodium azide. Store at 2-8°C|
|Precautions||Anti-HP / Haptoglobin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.|
|Tissue Location||Expressed by the liver and secreted in plasma.|
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