|Application ||WB, IHC-P, ICC, IP|
|Calculated MW||233175 Da|
|Dilution||ICC, IHC-P (5 µg/ml), IP, WB|
|Other Names||ESPL1, ESP1, Extra spindle poles like 1, KIAA0165, Caspase-like protein ESPL1, SEPA, Separase, Separin|
|Target/Specificity||Recognizes human Separase.|
|Reconstitution & Storage||TBS, pH 7.2, 0.1% BSA, 0.05% sodium azide Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Anti-ESPL1 / Separase Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.|
|Cellular Location||Cytoplasm. Nucleus.|
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