|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat|
|Calculated MW||74585 Da|
|Dilution||IHC-P (5 µg/ml), WB (1 - 2 µg/ml)|
|Other Names||ATF6, ATF6-alpha, ATF6A|
|Target/Specificity||Tested in humans, predicted to react with mouse and rat.|
|Reconstitution & Storage||5 mg BSA, 0.9 mg sodium chloride, 0.2 mg sodium phosphate, 0.05 mg Thimerosal, 0.05 mg sodium azide Short term +4°C; Long term -20°C|
|Precautions||Anti-ATF6 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'- ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type II membrane protein|
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