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Anti-SLC6A1 / GAT-1 Antibody (Internal)
Rabbit Anti Human Polyclonal Antibody
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Application 
| WB, IHC-P, IP |
|---|---|
| Primary Accession | P30531 |
| Predicted | Human, Mouse, Rat, Monkey, Pig, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 67074 Da |
| Dilution | IHC-P (1:100), IP (1:10 - 1:100), WB (1:500 - 1:1000) |
| Gene ID | 6529 |
|---|---|
| Alias Symbol | SLC6A1 |
| Other Names | SLC6A1, GABA transporter, GABA transporter 1, GABT1, GAT1, GABATHG, GABATR, GAT-1, GAT 1 |
| Target/Specificity | Recognizes endogenous levels of GAT1 protein. |
| Reconstitution & Storage | PBS, pH 7.3, 0.01% sodium azide, 30% glycerol. Store at -20°C. Aliquot to avoid freeze/thaw cycles. |
| Precautions | Anti-SLC6A1 / GAT-1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC6A1 |
|---|---|
| Synonyms | GABATR, GABT1, GAT1 |
| Function | Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse (PubMed:30132828). The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA (By similarity). The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(+), Cl(-) and GABA (By similarity). Can also mediate sodium- and chloride-dependent transport of hypotaurine but to a much lower extent as compared to GABA (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P23978}; Multi-pass membrane protein. Presynapse {ECO:0000250|UniProtKB:P31648}. Note=Localized at the presynaptic terminals of interneurons. {ECO:0000250|UniProtKB:P31648} |
Research Areas
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Application Protocols
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