|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat, Monkey|
|Calculated MW||86956 Da|
|Dilution||IHC-P (1:50), WB (1:500 - 1:1000)|
|Other Names||APLP2, Amyloid protein homolog, Amyloid-like protein 2, APLP-2, APPH, CDEI box-binding protein, CDEBP|
|Target/Specificity||Recognizes endogenous levels of APLP2 protein.|
|Reconstitution & Storage||PBS, pH 7.3, 0.01% sodium azide, 30% glycerol. Store at -20°C. Aliquot to avoid freeze/thaw cycles.|
|Precautions||Anti-APLP2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Nucleus|
|Tissue Location||Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues|
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