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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-MAD2L1 / MAD2 Antibody
Anti-MAD2L1 / MAD2 Antibody
Rabbit Anti Human Polyclonal Antibody
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Application 
| WB, IHC-P, IF |
|---|---|
| Primary Accession | Q13257 |
| Predicted | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 23510 Da |
| Dilution | IF (1:50 - 1:200), IHC-P (1:100), WB (1:500 - 1:2000) |
| Gene ID | 4085 |
|---|---|
| Alias Symbol | MAD2L1 |
| Other Names | MAD2L1, HSMAD2, MAD2, MAD2-like protein 1 |
| Target/Specificity | Human MAD2L1 / MAD2 |
| Reconstitution & Storage | PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. Long term: -80°C; Short term: -20°C. Avoid freeze-thaw cycles. |
| Precautions | Anti-MAD2L1 / MAD2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MAD2L1 |
|---|---|
| Synonyms | MAD2 |
| Function | Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:29162720, PubMed:15024386). In the closed conformation (C-MAD2) forms a heterotetrameric complex with MAD1L1 at unattached kinetochores during prometaphase, the complex recruits open conformation molecules of MAD2L1 (O-MAD2) and then promotes the conversion of O-MAD2 to C-MAD2 (PubMed:29162720). Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate (PubMed:10700282, PubMed:11804586, PubMed:15024386). |
| Cellular Location | Nucleus. Chromosome, centromere, kinetochore. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole Note=Recruited by MAD1L1 to unattached kinetochores (Probable) Recruited to the nuclear pore complex by TPR during interphase Recruited to kinetochores in late prometaphase after BUB1, CENPF, BUB1B and CENPE. Kinetochore association requires the presence of NEK2 Kinetochore association is repressed by UBD. Sequestered to the cytoplasm upon interaction with isoform 3 of MAD1L1 (PubMed:19010891) {ECO:0000269|PubMed:19010891, ECO:0000305} |
Research Areas
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