|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat|
|Calculated MW||57221 Da|
|Dilution||IHC-P (1:100), WB (1:500 - 1:2000)|
|Other Names||PTBP1, HnRNP I, HNRNPI, HNRPI, PTB, PPTB, PTB2, PTB4, RNA-binding protein, HNRNP-I, PTB-1, PTB-T, PTB3|
|Reconstitution & Storage||PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. Long term: -80°C; Short term: -20°C. Avoid freeze-thaw cycles.|
|Precautions||Anti-PTBP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (PubMed:15009664). In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:21518806).|
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