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Anti-PTBP1 Antibody
Rabbit Anti Human Polyclonal Antibody
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- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P26599 |
| Predicted | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 59633 Da |
| Dilution | IHC-P (1:100), WB (1:500 - 1:2000) |
| Gene ID | 5725 |
|---|---|
| Alias Symbol | PTBP1 |
| Other Names | PTBP1, HnRNP I, HNRNPI, HNRPI, PTB, PPTB, PTB2, PTB4, RNA-binding protein, HNRNP-I, PTB-1, PTB-T, PTB3 |
| Target/Specificity | Human PTBP1 |
| Reconstitution & Storage | PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. Long term: -80°C; Short term: -20°C. Avoid freeze-thaw cycles. |
| Precautions | Anti-PTBP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PTBP1 |
|---|---|
| Synonyms | PTB |
| Function | Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre- mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre- mRNA. Represses the splicing of MAPT/Tau exon 10 (PubMed:15009664). Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9 (PubMed:14966131). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES- mediated translation (PubMed:21518806). |
| Cellular Location | Nucleus. |
Research Areas
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Application Protocols
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