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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-AIMP1 / EMAP II Antibody
Anti-AIMP1 / EMAP II Antibody
Rabbit Anti Human Polyclonal Antibody
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- BACKGROUND
Application 
| WB, IHC-P, IF |
|---|---|
| Primary Accession | Q12904 |
| Predicted | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 34353 Da |
| Dilution | IF (1:50 - 1:200), IHC-P (1:100), WB (1:500 - 1:2000) |
| Gene ID | 9255 |
|---|---|
| Alias Symbol | AIMP1 |
| Other Names | AIMP1, EMAP II, EMAPII, EMAP-2, HLD3, p43, EMAP2, SCYE1 |
| Target/Specificity | Human AIMP1 / EMAP II / p43 |
| Reconstitution & Storage | PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. Long term: -80°C; Short term: -20°C. Avoid freeze-thaw cycles. |
| Precautions | Anti-AIMP1 / EMAP II Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AIMP1 |
|---|---|
| Synonyms | EMAP2, SCYE1 |
| Function | Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase (PubMed:10358004). Binds tRNA. Possesses inflammatory cytokine activity (PubMed:11306575). Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7- mediated degradation (By similarity). Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (By similarity). Promotes dermal fibroblast proliferation and wound repair (PubMed:16472771). Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (By similarity). Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations (PubMed:12237313). Induces maturation of dendritic cells and monocyte cell adhesion (PubMed:11818442). Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (PubMed:19362550). |
| Cellular Location | Nucleus. Cytoplasm, cytosol. Secreted. Endoplasmic reticulum {ECO:0000250|UniProtKB:P31230}. Golgi apparatus {ECO:0000250|UniProtKB:P31230}. Note=Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels (By similarity). Secreted in response to hypoxia (PubMed:10850427). Also secreted in response to both apoptotic and necrotic cell death. {ECO:0000250|UniProtKB:P31230, ECO:0000269|PubMed:10850427} |
Research Areas
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