|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat|
|Calculated MW||27216 Da|
|Dilution||IHC-P (1:100), WB (1:500 - 1:2000)|
|Other Names||TNFSF12, APO3/DR3 ligand, APO3L, DR3LG, APO3 ligand, TWEAK|
|Target/Specificity||Human TNFSF12 / TWEAK|
|Reconstitution & Storage||PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. Long term: -80°C; Short term: -20°C. Avoid freeze-thaw cycles.|
|Precautions||Anti-TNFSF12 / TWEAK Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein Isoform TWE-PRIL: Cell membrane; Single-pass membrane protein|
|Tissue Location||Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.