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Anti-TNFSF12 / TWEAK Antibody

Rabbit Anti Human Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession O43508
Predicted Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 27216 Da
Dilution IHC-P (1:100), WB (1:500 - 1:2000)
Additional Information
Gene ID 407977;8742
Alias Symbol TNFSF12
Other Names TNFSF12, APO3/DR3 ligand, APO3L, DR3LG, APO3 ligand, TWEAK
Target/Specificity Human TNFSF12 / TWEAK
Reconstitution & Storage PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. Long term: -80°C; Short term: -20°C. Avoid freeze-thaw cycles.
PrecautionsAnti-TNFSF12 / TWEAK Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNFSF12
Synonyms APO3L, DR3LG
Function Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.
Cellular Location Cell membrane; Single-pass type II membrane protein [Isoform TWE-PRIL]: Cell membrane; Single-pass membrane protein
Tissue Location Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain
Research Areas
Citations (0)
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Discontinued
Cat# ALS17364
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