|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat|
|Calculated MW||27216 Da|
|Dilution||IHC-P (1:100), WB (1:500 - 1:2000)|
|Other Names||TNFSF12, APO3/DR3 ligand, APO3L, DR3LG, APO3 ligand, TWEAK|
|Target/Specificity||Human TNFSF12 / TWEAK|
|Reconstitution & Storage||PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. Long term: -80°C; Short term: -20°C. Avoid freeze-thaw cycles.|
|Precautions||Anti-TNFSF12 / TWEAK Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein Isoform TWE-PRIL: Cell membrane; Single-pass membrane protein|
|Tissue Location||Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain|
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