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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-FPR2 / FPRL1 Antibody (C-Terminus)
Anti-FPR2 / FPRL1 Antibody (C-Terminus)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | P25090 |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 38964 Da |
| Dilution | IHC-P (2.5 - 5 µg/ml) |
| Gene ID | 2358 |
|---|---|
| Alias Symbol | FPR2 |
| Other Names | FPR2, ALXR, FMLP-R-I, FMLP-related receptor I, Fpr-rs1, FPRL1, FPR-like 1, Fprl-1, HM63, FMLP-R-II, FMLPX, Formyl peptide receptor-like 1, FPR2A, FPRH1, FPRH2, LXA4 receptor, LXA4R, Lipoxin A4 receptor, Lipoxin receptor, N-formyl peptide receptor 2, ... |
| Target/Specificity | Human FPR2 / FPRL1. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | PBS, less than 0.1% sodium azide. Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze thaw cycles. |
| Precautions | Anti-FPR2 / FPRL1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FPR2 |
|---|---|
| Synonyms | FPRH1, FPRL1, LXA4R |
| Function | Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (PubMed:1374236). Binding of FMLP to the receptor causes activation of neutrophils (PubMed:1374236). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1374236). The activation of LXA4R could result in an anti- inflammatory outcome counteracting the actions of pro-inflammatory signals such as LTB4 (leukotriene B4) (PubMed:9547339). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL- induced osteoclast differentiation (By similarity). Acts as a receptor for humanin (PubMed:15465011). |
| Cellular Location | Cell membrane; Multi-pass membrane protein Note=Associates with Amyloid-beta protein 42, product of APP, at the cell surface and the complex is then rapidly internalized (PubMed:11689470). Also internalized in the presence of humanin (PubMed:15465011). |
| Tissue Location | Detected in lung, bone marrow, neutrophils, spleen and testis. |
Research Areas
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$ 467.50
Cat# ALS17369
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