|Calculated MW||38964 Da|
|Dilution||IHC-P (2.5 - 5 µg/ml)|
|Other Names||FPR2, ALXR, FMLP-R-I, FMLP-related receptor I, Fpr-rs1, FPRL1, FPR-like 1, Fprl-1, HM63, FMLP-R-II, FMLPX, Formyl peptide receptor-like 1, FPR2A, FPRH1, FPRH2, LXA4 receptor, LXA4R, Lipoxin A4 receptor, Lipoxin receptor, N-formyl peptide receptor 2, ...|
|Target/Specificity||Human FPR2 / FPRL1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||PBS, less than 0.1% sodium azide. Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze thaw cycles.|
|Precautions||Anti-FPR2 / FPRL1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FPRH1, FPRL1, LXA4R|
|Function||Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis|
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