|Application ||WB, IHC-P, IP|
|Predicted||Human, Mouse, Rat, Pig|
|Calculated MW||47688 Da|
|Dilution||IHC-P (1:200), IP (1:10 - 1:100), WB (1:500 - 1:1000)|
|Other Names||CRHR2, CRF-R-2, CRF-R2, CRF2R, Crh2 receptor, CRF2 receptor, beta isoform, CRFR2, CRFR-2, CRH-R-2, CRH2R, CRF-RB, CRF2, CRH-R2, HM-CRF|
|Target/Specificity||Recognizes endogenous levels of CRHR2 protein.|
|Reconstitution & Storage||PBS, pH 7.3, 0.01% sodium azide, 30% glycerol. Store at -20°C. Aliquot to avoid freeze/thaw cycles.|
|Precautions||Anti-CRHR2 / CRF2 Receptor Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||G-protein coupled receptor for CRH (corticotropin- releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
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