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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-ATP6V1B2 Antibody (clone 1E11)
Anti-ATP6V1B2 Antibody (clone 1E11)
Mouse Anti Human Monoclonal Antibody
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Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P21281 |
| Predicted | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Clone Names | 1E11 |
| Calculated MW | 56501 Da |
| Dilution | IHC-P (1:100 - 1:150), WB (1:2000) |
| Gene ID | 526 |
|---|---|
| Alias Symbol | ATP6V1B2 |
| Other Names | ATP6V1B2, ATP6B1B2, ATP6B2, V-ATPase subunit B 2, Vma2, VATB, VPP3, HO57, V-ATPase B2 subunit |
| Target/Specificity | Human ATP6V1B2 |
| Reconstitution & Storage | PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide Store at -20°C. Minimize freezing and thawing. |
| Precautions | Anti-ATP6V1B2 Antibody (clone 1E11) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ATP6V1B2 |
|---|---|
| Synonyms | ATP6B2, VPP3 |
| Function | Non-catalytic subunit of the V1 complex of vacuolar(H+)- ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091). In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load (By similarity). |
| Cellular Location | Apical cell membrane. Melanosome. Cytoplasm {ECO:0000250|UniProtKB:P62814}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P62815}; Peripheral membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P62815}; Peripheral membrane protein. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV |
| Tissue Location | Kidney; localizes to early distal nephron, encompassing thick ascending limbs and distal convoluted tubules (at protein level). |
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