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Anti-SLC1A3 / EAAT1 Antibody (aa492-541)

Rabbit Anti Human Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P43003
Predicted Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 59572 Da
Dilution ELISA, IHC-P (1:200), WB
Additional Information
Gene ID 6507
Alias Symbol SLC1A3
Other Names SLC1A3, EA6, EAAT-1, EAAT1, GLAST, GLAST1, GLAST-1, GLUT-1
Target/Specificity EAAT1 antibody detects endogenous levels of EAAT1.
Reconstitution & Storage PBS, pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol Store at -20°C.
PrecautionsAnti-SLC1A3 / EAAT1 Antibody (aa492-541) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC1A3 (HGNC:10941)
Function Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:8123008, PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:20477940). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:20477940). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Detected in brain (PubMed:8218410, PubMed:7521911, PubMed:8123008). Detected at very much lower levels in heart, lung, placenta and skeletal muscle (PubMed:7521911, PubMed:8123008). Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia (PubMed:7521911).
Research Areas
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$ 467.50
Cat# ALS17376
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