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Anti-CCND2 / Cyclin D2 Antibody

Rabbit Anti Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P30279
Predicted Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 33067 Da
Dilution IHC-P (5 µg/ml), WB (1:500 - 1:2000)
Additional Information
Gene ID 894
Alias Symbol CCND2
Other Names CCND2, KIAK0002, G1/S-specific cyclin D2, G1/S-specific cyclin-D2, Cyclin D2
Target/Specificity Human CCND2 / Cyclin D2
Reconstitution & Storage PBS, 0.1% sodium azide, 50% glycerol. Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PrecautionsAnti-CCND2 / Cyclin D2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCND2
Function Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).
Cellular Location Nucleus. Cytoplasm. Membrane. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members
Research Areas
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$ 395.00
Cat# ALS17377
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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