|Application ||WB, IHC-P|
|Calculated MW||48058 Da|
|Dilution||IHC-P (10 µg/ml), WB|
|Other Names||KRT18, CK-18, Cytokeratin 18, Cytokeratin-18, K18, Keratin 18, CYK18, Keratin-18|
|Target/Specificity||Human KRT18 / CK18 / Cytokeratin 18|
|Reconstitution & Storage||PBS, 0.05% sodium azide. Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.|
|Precautions||Anti-KRT18 / CK18 / Cytokeratin 18 Antibody (clone DC10) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.|
|Cellular Location||Cytoplasm, perinuclear region. Nucleus, nucleolus|
|Tissue Location||Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.|
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