|Application ||WB, IHC-P|
|Calculated MW||27774 Da|
|Dilution||IHC-P (10 µg/ml), WB|
|Other Names||SFN, 14-3-3 sigma, 14-3-3 protein sigma, HME1, Stratifin, YWHAS|
|Target/Specificity||Human SFN / Stratifin / 14-3-3 Sigma|
|Reconstitution & Storage||PBS, 0.05% sodium azide. Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.|
|Precautions||Anti-SFN / Stratifin / 14-3-3 Sigma Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.|
|Cellular Location||Cytoplasm. Nucleus. Secreted. Note=May be secreted by a non-classical secretory pathway|
|Tissue Location||Present mainly in tissues enriched in stratified squamous keratinizing epithelium|
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