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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-SFN / Stratifin / 14-3-3 Sigma Antibody
Anti-SFN / Stratifin / 14-3-3 Sigma Antibody
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
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- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P31947 |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 27774 Da |
| Dilution | IHC-P (10 µg/ml), WB |
| Gene ID | 2810 |
|---|---|
| Alias Symbol | SFN |
| Other Names | SFN, 14-3-3 sigma, 14-3-3 protein sigma, HME1, Stratifin, YWHAS |
| Target/Specificity | Human SFN / Stratifin / 14-3-3 Sigma |
| Reconstitution & Storage | PBS, 0.05% sodium azide. Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Precautions | Anti-SFN / Stratifin / 14-3-3 Sigma Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SFN |
|---|---|
| Synonyms | HME1 {ECO:0000303|PubMed:1390337} |
| Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binding generally results in the modulation of the activity of the binding partner (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (PubMed:37797010). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (PubMed:9659898). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (PubMed:18382127). |
| Cellular Location | Cytoplasm, cytosol. Nucleus {ECO:0000250|UniProtKB:O70456}. Secreted. Note=May be secreted by a non-classical secretory pathway. |
| Tissue Location | Present mainly in tissues enriched in stratified squamous keratinizing epithelium. |
Research Areas
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