|Application ||WB, IHC-P|
|Calculated MW||65835 Da|
|Dilution||IHC-P (5 µg/ml), WB|
|Other Names||TRIM29, ATDC, Tripartite motif containing 29, Tripartite motif-containing 29|
|Reconstitution & Storage||PBS, 0.05% sodium azide. Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.|
|Precautions||Anti-TRIM29 Antibody (aa4-129) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of TMEM173/STING in a similar way, leading to its degradation.|
|Cellular Location||Cytoplasm. Lysosome. Note=Colocalizes with intermediate filaments|
|Tissue Location||Expressed in placenta, prostate and thymus.|
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