|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat, Rabbit|
|Calculated MW||16133 Da|
|Dilution||IHC-P (1:100), WB (1:500 - 1:1000)|
|Other Names||ID1, BHLHb24, ID, Inhibitor of differentiation 1, Inhibitor of DNA binding 1, DJ857M17.1.2|
|Target/Specificity||Recognizes endogenous levels of ID1 protein.|
|Reconstitution & Storage||PBS, pH 7.3, 0.01% sodium azide, 30% glycerol. Store at -20°C. Aliquot to avoid freeze/thaw cycles.|
|Precautions||Anti-ID / ID1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).|
|Cellular Location||Cytoplasm. Nucleus.|
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