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Anti-SLC25A11 Antibody (Internal)

Rabbit Anti Human Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q02978
Predicted Human, Mouse, Rat, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 34062 Da
Dilution IHC-P (1:100), WB (1:500 - 1:1000)
Additional Information
Gene ID 8402
Alias Symbol SLC25A11
Other Names SLC25A11, OGC, SLC20A4, OGCP, Oxoglutarate carrier, Oxoglutarate translocator, Oxoglutarate/malate carrier
Target/Specificity Recognizes endogenous levels of SLC25A11 protein.
Reconstitution & Storage PBS, pH 7.3, 0.01% sodium azide, 30% glycerol. Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsAnti-SLC25A11 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC25A11
Synonyms SLC20A4
Function Catalyzes the transport of 2-oxoglutarate (alpha- oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate. Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity. Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (PubMed:21448454). Involved in the regulation of apoptosis (By similarity). Helps protect from cytotoxic-induced apoptosis by modulating glutathione levels in mitochondria (By similarity).
Cellular Location Mitochondrion inner membrane {ECO:0000250|UniProtKB:P97700}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P97700}
Tissue Location Most highly expressed in the heart.
Research Areas
Citations (0)
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Discontinued
Cat# ALS17423
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