|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat|
|Calculated MW||60868 Da|
|Dilution||IHC-P (10 µg/ml), WB (1 - 2 µg/ml)|
|Other Names||BAIAP2, BAI-associated protein 2, BAI1-associated protein 2, BAP2, FLAF3, Fas ligand-associated factor 3, IRSP53, IRS-58, Protein BAP2, Insulin receptor substrate p53, IRSp53/58|
|Target/Specificity||Endogenous levels of human, mouse and rat BAIAP2 protein. Positive Control: U251, mouse brain and rat brain.|
|Reconstitution & Storage||Lyophilized from PBS, pH 7.4, 0.02% sodium azide. Store lyophilized at -20°C. The reconstituted product can be stored for short term at 4 °C or long term at -20 °C or below. Avoid freeze/thaw cycles.|
|Precautions||Anti-BAIAP2 / IRSP53 Antibody (aa350-400) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle Cytoplasm, cytoskeleton. Note=Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites|
|Tissue Location||Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta|
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