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Anti-NR5A1 / SF1 Antibody (Internal)

Rabbit Anti Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13285
Predicted Human, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 51636 Da
Dilution IHC-P (2 - 18 µg/ml)
Additional Information
Gene ID 2516
Alias Symbol NR5A1
Other Names NR5A1, AD4BP, Adrenal 4 binding protein, Adrenal 4-binding protein, ELP, Steroidogenic factor-1, SRXY3, Steroidogenic factor 1, Nuclear receptor AdBP4, Nuclear receptor elp, POF7, SF-1, SPGF8, Steroid hormone receptor Ad4BP, STF-1, FTZ1, FTZF1, Fushi ...
Target/Specificity Human NR5A1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except TRIM23 (47%).
Reconstitution & Storage Immunoaffinity purified
PrecautionsAnti-NR5A1 / SF1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NR5A1
Synonyms AD4BP, FTZF1, SF1
Function Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO- NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:11479297}
Research Areas
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$ 395.00
Cat# ALS17484
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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