Anti-EAR2 / NR2F6 Antibody (N-Terminus)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
---|---|
Primary Accession | P10588 |
Predicted | Human, Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 42979 Da |
Dilution | IHC-P (4 µg/ml) |
Gene ID | 2063 |
---|---|
Alias Symbol | NR2F6 |
Other Names | NR2F6, Erba related 2, ERBAL2, EAR-2, EAR2, ERBA-related gene-2, V-erbA-related protein 2 |
Target/Specificity | Human NR2F6. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
Reconstitution & Storage | Immunoaffinity purified |
Precautions | Anti-EAR2 / NR2F6 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NR2F6 |
---|---|
Synonyms | EAR2, ERBAL2 |
Function | Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin- choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine- dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:18701084} |
Tissue Location | Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.