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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-CHRM2 / M2 Antibody (Cytoplasmic Domain)
Anti-CHRM2 / M2 Antibody (Cytoplasmic Domain)
Rabbit Anti Human Polyclonal Antibody
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Application 
| IHC-P |
|---|---|
| Primary Accession | P08172 |
| Predicted | Human, Rabbit, Monkey, Sheep, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 51715 Da |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 1129 |
|---|---|
| Alias Symbol | CHRM2 |
| Other Names | CHRM2, 7TM receptor, HM2, M2 muscarinic receptor, M2-mAChR, Muscarinic receptor M2, Muscarinic M2 receptor |
| Target/Specificity | Human CHRM2. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-CHRM2 / M2 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CHRM2 |
|---|---|
| Function | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Note=Phosphorylation in response to agonist binding promotes receptor internalization {ECO:0000250|UniProtKB:P06199} |
Research Areas
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