|Predicted||Human, Rabbit, Monkey, Sheep, Bovine|
|Calculated MW||51715 Da|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||CHRM2, 7TM receptor, HM2, M2 muscarinic receptor, M2-mAChR, Muscarinic receptor M2, Muscarinic M2 receptor|
|Target/Specificity||Human CHRM2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-CHRM2 / M2 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Phosphorylation in response to agonist binding promotes receptor internalization.|
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