|Calculated MW||35248 Da|
|Dilution||IHC-P (18 µg/ml)|
|Other Names||GPBAR1, BG37, GPR131, HGPCR19, M-BAR, GPCR19, TGR5, GPCR TGR5, HBG37, Membrane bile acid receptor|
|Target/Specificity||Human TGR5. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-GPBAR1 / TGR5 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum.|
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