|Calculated MW||37731 Da|
|Dilution||IHC-P (1 - 2 µg/ml)|
|Other Names||GNRHR, GnRH receptor, GnRH-R, GRHR, HH7, LHRHR, LRHR, Luliberin receptor, Type I GnRH receptor, GNRHR1, Lh-rh receptor|
|Target/Specificity||Human GNRHR. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-GnRH receptor / GNRHR Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle- stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol- calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Pituitary, ovary, testis, breast and prostate but not in liver and spleen|
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