|Calculated MW||36118 Da|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||MRGPRD, Beta-alanine receptor, MRGD, MAS-related GPR, member D, TGR7|
|Target/Specificity||Human MRGPRD. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-MRGD / MRGPRD Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin- stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).|
|Cellular Location||Cell membrane; Multi-pass membrane protein Note=Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine|
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