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Anti-OPRK1 / Kappa Opioid Receptor Antibody (Extracellular Domain)

Rabbit Anti Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P41145
Predicted Human, Rat, Rabbit, Monkey, Horse, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 42645 Da
Dilution IHC-P (4 µg/ml)
Additional Information
Gene ID 4986
Alias Symbol OPRK1
Other Names OPRK1, Kappa-type opioid receptor, Opiate receptor, kappa-1, K-OR-1, KOR, Opioid receptor, kappa 1, OPRK, Ork1, Kappa opioid receptor, KOR-1, Opioid receptor kappa
Target/Specificity Human Kappa Opioid Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Immunoaffinity purified
PrecautionsAnti-OPRK1 / Kappa Opioid Receptor Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name OPRK1
Synonyms OPRK
Function G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Detected in brain and placenta.
Research Areas
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$ 395.00
Cat# ALS17546
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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