|Application ||IHC-P, E|
|Calculated MW||64466 Da|
|Dilution||ELISA, IHC-P (10 µg/ml)|
|Other Names||FZD9, CD349, Frizzled homolog 9, Fz-9, Frizzled family receptor 9, Frizzled-9, Frizzled 9, Fz9, HFz9, CD349 antigen, Frizzled homolog fzd3, FzE6|
|Target/Specificity||Human FZD9 / Frizzled 9. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except FZD10 (47%).|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-FZD9 / Frizzled 9 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed predominantly in adult and fetal brain, testis, eye, skeletal muscle and kidney. Moderately expressed in pancreas, thyroid, adrenal cortex, small intestine and stomach. Detected in fetal liver and kidney|
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