|Predicted||Human, Mouse, Hamster, Horse|
|Calculated MW||23946 Da|
|Dilution||IHC-P (10 - 20 µg/ml)|
|Other Names||DUSP26, DSP-4, NATA1, SKRP3, MAP kinase phosphatase 8, MKP-8, DUSP24, LDP-4, LDP4, MKP8|
|Target/Specificity||Human DUSP26. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-DUSP26 / MKP8 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DUSP24, LDP4, MKP8, NATA1, SKRP3|
|Function||Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).|
|Cellular Location||Cytoplasm. Nucleus. Golgi apparatus.|
|Tissue Location||Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer.|
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