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Anti-DUSP26 / MKP8 Antibody (Internal)
Rabbit Anti Human Polyclonal Antibody
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Application 
| IHC-P |
|---|---|
| Primary Accession | Q9BV47 |
| Predicted | Human, Mouse, Hamster, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 23946 Da |
| Dilution | IHC-P (10 - 20 µg/ml) |
| Gene ID | 78986 |
|---|---|
| Alias Symbol | DUSP26 |
| Other Names | DUSP26, DSP-4, NATA1, SKRP3, MAP kinase phosphatase 8, MKP-8, DUSP24, LDP-4, LDP4, MKP8 |
| Target/Specificity | Human DUSP26. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-DUSP26 / MKP8 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DUSP26 |
|---|---|
| Synonyms | DUSP24, LDP4, MKP8, NATA1, SKRP3 |
| Function | Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). |
| Cellular Location | Cytoplasm. Nucleus. Golgi apparatus. |
| Tissue Location | Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer. |
Research Areas
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