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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-GJA1 / CX43 / Connexin 43 Antibody (Internal)
Anti-GJA1 / CX43 / Connexin 43 Antibody (Internal)
Rabbit Anti Human Polyclonal Antibody
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Application 
| IHC-P |
|---|---|
| Primary Accession | P17302 |
| Predicted | Human, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 43008 Da |
| Dilution | IHC-P (2.5 - 5 µg/ml) |
| Gene ID | 2697 |
|---|---|
| Alias Symbol | GJA1 |
| Other Names | GJA1, Connexin-43, DFNB38, Connexin 43, Gap junction alpha-1 protein, GJAL, HSS, Gap junction protein alpha 1, ODDD, ODD, AVSD3, CX43, HLHS1, ODOD, SDTY3 |
| Target/Specificity | Human GJA1 / Connexin 43. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-GJA1 / CX43 / Connexin 43 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GJA1 |
|---|---|
| Synonyms | GJAL |
| Function | Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Endoplasmic reticulum {ECO:0000250|UniProtKB:P23242}. Note=Localizes at the intercalated disk (ICD) in cardiomyocytes and the proper localization at ICD is dependent on TMEM65. {ECO:0000250|UniProtKB:P23242} |
| Tissue Location | Expressed in the heart and fetal cochlea. |
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