|Calculated MW||226372 Da|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||SCN9A, ETHA, GEFSP7, Nav1.7, HNE-Na, Peripheral sodium channel 1, PN1, SFNP, Sodium channel 25, Neuroendocrine sodium channel, FEB3B, NE-NA, NENA|
|Target/Specificity||Human SCN9A / Nav1.7. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except SCN8A (71%).|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-SCN9A / Nav1.7 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain (By similarity).|
|Cellular Location||Membrane; Multi-pass membrane protein. Note=In neurite terminals.|
|Tissue Location||Expressed strongly in dorsal root ganglion, with only minor levels elsewhere in the body, smooth muscle cells, MTC cell line and C-cell carcinoma. Isoform 1 is expressed preferentially in the central and peripheral nervous system Isoform 2 is expressed preferentially in the dorsal root ganglion|
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