|Application ||WB, IHC-P, E|
|Predicted||Human, Mouse, Rat, Hamster, Monkey, Chicken|
|Calculated MW||95338 Da|
|Dilution||ELISA, IHC-P (1:100), WB (1:1000)|
|Other Names||EEF2, EEF-2, EF-2, Elongation factor 2, Polypeptidyl-tRNA translocase, EF2|
|Target/Specificity||Detects endogenous levels of eEF2 only when phosphorylated at threonine 56. It does not recognize eEF2 phosphorylated at other sites.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-EEF2 / Elongation Factor 2 Antibody (phospho-Thr56) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|
|Cellular Location||Cytoplasm. Nucleus. Note=Phosphorylation by CSK promotes cleavage and SUMOylation-dependent nuclear translocation of the C-terminal cleavage product.|
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