|Application ||WB, IHC-P, ICC, Flo|
|Calculated MW||31223 Da|
|Dilution||Flo, ICC, IHC-P (10 µg/ml), WB|
|Other Names||TNFSF13B, B-cell-activating factor, BAFF, ApoL related ligand TALL-1, B-lymphocyte stimulator, CD257, BLYS, Delta4 BAFF, Delta BAFF, TALL-1, TALL1, ZTNF4, THANK, B lymphocyte stimulator, CD257 antigen, TNFSF20|
|Target/Specificity||Recognizes membrane-bound human BAFF. Detects endogenous protein by FC.|
|Reconstitution & Storage||Gel filtration|
|Precautions||Anti-BAFF Antibody (aa83-285, clone Buffy-1) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||BAFF, BLYS, TALL1, TNFSF20, ZTNF4|
|Function||Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein|
|Tissue Location||Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T- cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines|
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