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Anti-ATF6 Antibody (aa1-273, clone 70B1413.1)
Mouse Anti Human Monoclonal Antibody
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Application 
| WB, IHC-P, ICC, CHIP |
|---|---|
| Primary Accession | P18850 |
| Predicted | Human, Mouse, Rat, Hamster |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1,k |
| Clone Names | 70B1413.1 |
| Calculated MW | 74585 Da |
| Dilution | ChrIP, ICC, IHC-P (10 µg/ml), WB (1 - 3 µg/ml) |
| Gene ID | 22926 |
|---|---|
| Alias Symbol | ATF6 |
| Other Names | ATF6, ATF6-alpha, ATF6A |
| Target/Specificity | A partial protein containing amino acids 1-273 of human ATF6. |
| Reconstitution & Storage | Protein G purified |
| Precautions | Anti-ATF6 Antibody (aa1-273, clone 70B1413.1) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ATF6 |
|---|---|
| Function | Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'- ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina. |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type II membrane protein |
| Tissue Location | Ubiquitous. |
Research Areas
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$ 395.00
Cat# ALS17598
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