|Application ||WB, IHC-P|
|Calculated MW||24894 Da|
|Dilution||IHC-P (5 µg/ml), WB (1 - 2 µg/ml)|
|Other Names||HMGB1, Amphoterin, High mobility group protein B1, High mobility group box 1, High mobility group protein 1, HMG1, HMG3, SBP-1, High-mobility group box 1, HMG-1|
|Target/Specificity||Recognizes HMGB1/HMG 1, Mr 32kD. Species cross-reactivity: Human. Broad species cross-reactivity is expected.|
|Reconstitution & Storage||Protein A purified|
|Precautions||Anti-HMG1 / HMGB1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity).|
|Cellular Location||Nucleus. Chromosome.|
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