|Application ||IHC-P, E|
|Predicted||Human, Rabbit, Monkey|
|Calculated MW||30771 Da|
|Dilution||ELISA, IHC-P (5 µg/ml)|
|Other Names||PDX1, Glucose-sensitive factor, Insulin upstream factor 1, IPF1, Insulin promoter factor 1, IPF-1, IUF-1, STF-1, GSF, IDX-1, Islet/duodenum homeobox-1, IUF1, MODY4, PDX-1|
|Target/Specificity||Recognizes human Pdx1. Species cross-reactivity: rodent.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-PDX1 Antibody (aa198-213) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.|
|Cellular Location||Nucleus. Cytoplasm, cytosol.|
|Tissue Location||Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells)|
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