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Anti-UMOD / Uromodulin Antibody (clone 10.32, FITC)

Mouse Anti Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P07911
Predicted Human, Dog
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Clone Names 10.32
Calculated MW 69761 Da
Dilution ELISA, IF, IHC-Fr, IHC-P (1:50)
Additional Information
Gene ID 7369
Alias Symbol UMOD
Other Names UMOD, ADMCKD2, FJHN, HNFJ, MCKD2, THGP, THP, Uromucoid, Tamm-Horsfall glycoprotein, HNFJ1, Uromodulin
Target/Specificity Anti-human Tamm-Horsfall protein (THP) is a monoclonal antibody which reacts with an epitope of the urinary mucoprotein. Tamm-Horsfall protein is a glycoprotein of approximately 80 kD containing up to 25% carbohydrate by weight.
Reconstitution & Storage Protein G purified
PrecautionsAnti-UMOD / Uromodulin Antibody (clone 10.32, FITC) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure providing the water barrier permeability. May serve as a receptor for binding and endocytosis for cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelial.
Cellular Location Apical cell membrane; Lipid- anchor, GPI-anchor. Basolateral cell membrane; Lipid-anchor, GPI- anchor. Cell projection, cilium membrane. Note=Only a small fraction sorts to the basolateral pole of tubular epithelial cells compared to apical localization. Secreted into urine after cleavage. Colocalized with NPHP1 and KIF3A
Tissue Location Expressed in the tubular cells of the kidney (at protein level). Synthesized exclusively in the kidney Expressed exclusively by epithelial cells of the thick ascending limb of Henle's loop (TALH) and of distal convoluted tubule lumen Most abundant protein in normal urine
Research Areas
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$ 395.00
Cat# ALS17606
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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