|Application ||WB, IHC-P, Flo|
|Predicted||Human, Mouse, Rat, Bovine, Dog|
|Calculated MW||32819 Da|
|Dilution||Flo, IHC-P (10 µg/ml), WB (1:250)|
|Other Names||HMOX1, BK286B10, HO-1, HSP32, Heat shock protein, 32-kD, Heme oxygenase (decycling) 1, Heme oxygenase 1, HO1|
|Reconstitution & Storage||Protein G purified|
|Precautions||Anti-HMOX1 / HO-1 Antibody (clone 5F12-B10) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.|
|Cellular Location||Microsome. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side|
|Tissue Location||Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level)|
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