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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-NCKAP1L Antibody
Anti-NCKAP1L Antibody
Goat Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | P55160 |
| Predicted | Human, Mouse, Rat, Rabbit, Hamster, Monkey, Bovine, Horse, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 128153 Da |
| Dilution | IHC-P (3.75 µg/ml) |
| Gene ID | 3071 |
|---|---|
| Alias Symbol | NCKAP1L |
| Other Names | NCKAP1L, HEM1, Hematopoietic protein 1, NCK-associated protein 1-like |
| Target/Specificity | Human NCKAP1L. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-NCKAP1L Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NCKAP1L (HGNC:4862) |
|---|---|
| Function | Essential hematopoietic-specific regulator of the actin cytoskeleton (Probable). Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages (PubMed:16417406, PubMed:17696648). Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells (By similarity). Within the WAVE2 complex, enables the cortical actin network to restrain excessive degranulation and granule release by T-cells (PubMed:32647003). Required for efficient T-lymphocyte and neutrophil migration (PubMed:32647003). Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin (PubMed:16417406). Also involved in mechanisms WAVE-independent to regulate myosin and actin polymerization during neutrophil chemotaxis (PubMed:17696648). In T-cells, required for proper mechanistic target of rapamycin complex 2 (mTORC2)-dependent AKT phosphorylation, cell proliferation and cytokine secretion, including that of IL2 and TNF (PubMed:32647003). |
| Cellular Location | Cell membrane; Single-pass membrane protein; Cytoplasmic side. Cytoplasm. Note=Localizes to the leading edge of polarized neutrophils |
| Tissue Location | Expressed only in cells of hematopoietic origin (PubMed:7643388, PubMed:1932118). Expressed in neutrophils (at protein level) (PubMed:16417406). Expressed in T-cells (at protein level) (PubMed:32647003). |
Research Areas
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