|Application ||IHC-P, IHC-F, E, RIA|
|Calculated MW||309265 Da|
|Dilution||ELISA, IHC-Fr (1:50), IHC-P (10 µg/ml), RIA|
|Other Names||VWF, Coagulation factor VIII VWF, F8VWF, VWD, Von Willebrand factor|
|Target/Specificity||Reacts with human von Willebrand's factor (also known as Factor VIII related antigen) in both plasma and tissues. Does not have anti-coagulant activity.|
|Reconstitution & Storage||Protein A purified|
|Precautions||Anti-VWF / Von Willebrand Factor Antibody (clone 21-43) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.|
|Cellular Location||Secreted. Secreted, extracellular space, extracellular matrix. Note=Localized to storage granules|
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