Anti-CLIC1 / NCC27 Antibody (clone 2D4)
Mouse Anti Human Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | O00299 |
Predicted | Human |
Host | Mouse |
Clonality | Monoclonal |
Isotype | IgG1,k |
Clone Names | 2D4 |
Calculated MW | 26923 Da |
Dilution | ELISA, IHC-P (5 µg/ml), WB |
Gene ID | 1192 |
---|---|
Alias Symbol | CLIC1 |
Other Names | CLIC1, Chloride channel ABP, G6, Nuclear chloride channel-27, p64CLCP, RNCC protein, HRNCC, NCC27 |
Reconstitution & Storage | Protein A purified |
Precautions | Anti-CLIC1 / NCC27 Antibody (clone 2D4) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CLIC1 |
---|---|
Synonyms | G6, NCC27 |
Function | Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle. |
Cellular Location | Nucleus. Nucleus membrane; Single-pass membrane protein. Cytoplasm. Cell membrane; Single-pass membrane protein. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q6MG61}. Note=Mostly in the nucleus including in the nuclear membrane (PubMed:9139710, PubMed:12681486). Small amount in the cytoplasm and the plasma membrane (PubMed:9139710). Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (PubMed:11940526, PubMed:11551966, PubMed:14613939, PubMed:12681486, PubMed:9139710). Might not be present in the nucleus of cardiac cells (By similarity) {ECO:0000250|UniProtKB:Q6MG61, ECO:0000269|PubMed:11551966, ECO:0000269|PubMed:11940526, ECO:0000269|PubMed:12681486, ECO:0000269|PubMed:14613939, ECO:0000269|PubMed:9139710} |
Tissue Location | Expression is prominent in heart, placenta, liver, kidney and pancreas. |
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