|Application ||WB, IHC-P, E|
|Calculated MW||26923 Da|
|Dilution||ELISA, IHC-P (5 µg/ml), WB|
|Other Names||CLIC1, Chloride channel ABP, G6, Nuclear chloride channel-27, p64CLCP, RNCC protein, HRNCC, NCC27|
|Reconstitution & Storage||Protein A purified|
|Precautions||Anti-CLIC1 / NCC27 Antibody (clone 2D4) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.|
|Cellular Location||Nucleus. Nucleus membrane; Single-pass membrane protein. Cytoplasm. Cell membrane; Single-pass membrane protein. Note=Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain|
|Tissue Location||Expression is prominent in heart, placenta, liver, kidney and pancreas.|
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