|Application ||WB, IHC-P, E|
|Calculated MW||128109 Da|
|Dilution||ELISA, IHC-P (5 µg/ml), WB|
|Other Names||MCF2L, ARHGEF14, DBS, KIAA0362, OST, DBLs big sister|
|Reconstitution & Storage||Protein A purified|
|Precautions||Anti-MCF2L / DBS Antibody (clone 1D11) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Guanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42.|
|Cellular Location||Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side|
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