|Application ||WB, IHC-P, ICC, E|
|Calculated MW||115860 Da|
|Dilution||ELISA, ICC (1:200), IHC-P (2.5 µg/ml), WB|
|Other Names||TLR9, CD289, CD289 antigen, Scri2a, Toll-like receptor 9|
|Target/Specificity||Peptide sequence is <50 % identical to other mouse TLR receptors in this region. The antibody recognizes mouse TLR9 and human TLR9.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-TLR9 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type I membrane protein Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.|
|Tissue Location||Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre- dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver|
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