|Application ||WB, IHC-P, E|
|Calculated MW||47573 Da|
|Dilution||ELISA, IHC-P (5 µg/ml), WB|
|Other Names||SYT1, SYT, SVP65, Synaptotagmin, Synaptotagmin 1, SytI, Synaptotagmin I, Synaptotagmin-1|
|Target/Specificity||Human Synaptotagmin I|
|Reconstitution & Storage||Protein A purified|
|Precautions||Anti-SYT1 / Synaptotagmin Antibody (clone 1A6) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Cytoplasm. Note=Synaptic vesicles and chromaffin granules|
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