Anti-GPR171 Antibody (Extracellular Domain)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
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Primary Accession | O14626 |
Predicted | Human, Rabbit, Monkey, Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 36754 Da |
Dilution | IHC-P (10 - 20 µg/ml) |
Gene ID | 29909 |
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Alias Symbol | GPR171 |
Other Names | GPR171, H963, G protein-coupled receptor 171 |
Target/Specificity | Human GPR171. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
Reconstitution & Storage | Immunoaffinity purified |
Precautions | Anti-GPR171 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GPR171 (HGNC:30057) |
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Synonyms | H963 |
Function | G-protein coupled receptor for Big LEN, a 16-amino acid neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)-alpha-mediated pathway in response to Big LEN. Big LEN-GPR171 system plays an important role in regulating feeding and metabolism. Also plays a role in modulating fear and anxiety-like behaviors in the basolateral amygdala. Big LEN-GPR171 modulates the mu-type opioid receptor signaling and antinociception (By similarity). Acts as a negative regulator T cell function (PubMed:34615877). |
Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q8BG55}; Multi-pass membrane protein. Note=Colocalized with GPR83 in the paraventricular nucleus. {ECO:0000250|UniProtKB:Q8BG55} |
Tissue Location | Expressed in both T-cell subsets and natural killer cells, while it is undetectable in B cells or CD14(+) monocytes Expressed in peripheral blood mononuclear cells (PBMC) and Jurkat cells (at protein level). |
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