|Calculated MW||35293 Da|
|Dilution||IHC-P (10 - 15 µg/ml)|
|Other Names||ELOVL5, ELOVL FA elongase 5, ELOVL fatty acid elongase 5, Fatty acid elongase 1, RP3-483K16.1, DJ483K16.1, HELO1|
|Target/Specificity||Human ELOVL5. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-HELO1 / ELOVL5 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=In Purkinje cells, the protein localizes to the soma and proximal portion of the dendritic tree|
|Tissue Location||Ubiquitous. Highly expressed in the adrenal gland and testis. Weakly expressed in prostate, lung and brain Expressed in the cerebellum.|
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