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Anti-Spastin Antibody (clone 2F5)

Mouse Anti Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UBP0
Predicted Human
Host Mouse
Clonality Monoclonal
Isotype IgG1,k
Clone Names 2F5
Calculated MW 67197 Da
Dilution ELISA, IHC-P (5 µg/ml), WB (1:500 - 1:1000)
Additional Information
Gene ID 6683
Alias Symbol SPAST
Other Names SPAST, ADPSP, KIAA1083, FSP2, Spastin, Spastic paraplegia 4 protein, SPG4
Target/Specificity Human Spastin Protein
Reconstitution & Storage Protein A purified
PrecautionsAnti-Spastin Antibody (clone 2F5) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SPAST {ECO:0000255|HAMAP-Rule:MF_03021}
Function ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. May also play a role in axon growth and the formation of axonal branches.
Cellular Location Membrane {ECO:0000255|HAMAP-Rule:MF_03021}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03021} Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Endoplasmic reticulum. Endosome. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Localization to the centrosome is independent of microtubules. Localizes to the midbody of dividing cells, and this requires CHMP1B. Enriched in the distal axons and branches of postmitotic neurons. Isoform 3 is the main endosomal form
Tissue Location Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. The short isoforms may predominate in brain and spinal cord
Research Areas
Citations (0)

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$ 450.00
Cat# ALS17683
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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