|Application ||WB, IHC-P, E|
|Calculated MW||84871 Da|
|Dilution||ELISA, IHC-P (5 µg/ml), WB (1:500 - 1:1000)|
|Other Names||TFRC, CD71, TFR1, TRFR, TFR, TR, CD71 antigen, p90, T9, Transferrin receptor, Transferrin receptor protein 1|
|Target/Specificity||Human Transferrin Receptor|
|Reconstitution & Storage||Protein A purified|
|Precautions||Anti-CD71 / Transferrin Receptor Antibody (clone 1E6) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).|
|Cellular Location||Cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
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