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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-SNAPIN Antibody (clone 3H1)
Anti-SNAPIN Antibody (clone 3H1)
Mouse Anti Human Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | O95295 |
| Predicted | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1,k |
| Clone Names | 3H1 |
| Calculated MW | 14874 Da |
| Dilution | ELISA, IHC-P (3 - 5 µg/ml), WB (1:500 - 1:1000) |
| Gene ID | 23557 |
|---|---|
| Alias Symbol | SNAPIN |
| Other Names | SNAPIN, BLOC1S7, SNAP-associated protein, SNAP-25-binding protein, SNAP25BP, SNAPAP |
| Target/Specificity | Human SNAPIN |
| Reconstitution & Storage | Protein A purified |
| Precautions | Anti-SNAPIN Antibody (clone 3H1) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SNAPIN |
|---|---|
| Synonyms | BLOC1S7, SNAP25BP, SNAPAP |
| Function | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE- mediated membrane fusion in non-neuronal cells (PubMed:17182842, PubMed:18167355). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). |
| Cellular Location | Membrane {ECO:0000250|UniProtKB:Q9Z266}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9Z266}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z266}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Z266}. Cytoplasm, perinuclear region. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9Z266}. Lysosome membrane. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Note=Colocalizes with NANOS1 and PUM2 in the perinuclear region of germ cells. |
| Tissue Location | Expressed in male germ cells of adult testis (at protein level). |
Research Areas
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Discontinued
Cat# ALS17711
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