|Application ||WB, IHC-P, E|
|Calculated MW||14874 Da|
|Dilution||ELISA, IHC-P (3 - 5 µg/ml), WB (1:500 - 1:1000)|
|Other Names||SNAPIN, BLOC1S7, SNAP-associated protein, SNAP-25-binding protein, SNAP25BP, SNAPAP|
|Reconstitution & Storage||Protein A purified|
|Precautions||Anti-SNAPIN Antibody (clone 3H1) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||BLOC1S7, SNAP25BP, SNAPAP|
|Function||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma- membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells.|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasm, perinuclear region. Golgi apparatus membrane. Cytoplasmic vesicle, secretory vesicle. Note=May be cytoplasmic and peripheral membrane bound or anchored to the vesicular membrane through an N- terminal signal anchor (By similarity). Colocalizes with NANOS1 and PUM2 in the perinuclear region of germ cells.|
|Tissue Location||Expressed in male germ cells of adult testis (at protein level).|
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